Abstract
We report serial CNS findings in a girl with sickle cell disease and stroke. Religious considerations precluded transfusion and bone marrow transplantation; therefore, she received single-agent hydroxyurea therapy for almost 6 years. MR angiography showed that vascular patency improved, although diffuse cerebral atrophy slowly worsened. Hydroxyurea can be effective in treating vasculopathy, but it might not prevent the progression of parenchymal damage in advanced disease.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antisickling Agents / therapeutic use*
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Brain / diagnostic imaging
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Brain / metabolism
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Brain / physiopathology
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Child
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Combined Modality Therapy
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Disease Progression
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Female
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Fetal Hemoglobin / drug effects
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Fetal Hemoglobin / metabolism
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Hemoglobin SC Disease / complications
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Hemoglobin SC Disease / prevention & control*
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Hemoglobin SC Disease / surgery*
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Humans
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Hydroxyurea / therapeutic use*
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Magnetic Resonance Angiography
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Radiography
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Stroke / drug therapy
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Stroke / etiology
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Stroke / surgery
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Vascular Diseases / complications
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Vascular Diseases / prevention & control*
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Vascular Patency / drug effects
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Vascular Patency / physiology
Substances
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Antisickling Agents
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Fetal Hemoglobin
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Hydroxyurea