Solid-phase synthesis of combinatorial libraries based on enatiomerically pure (1S,2S,4R,5S)-4,5-dihydroxycyclohexan-1,2-dicarboxylic acid scaffolds

Farmaco. 2002 Oct;57(10):861-4. doi: 10.1016/s0014-827x(02)01306-x.

Abstract

The conditions for solid-phase functionalization of the new enantio-pure scaffold 1 to give libraries of general formula 4 have been derived.

MeSH terms

  • Chemistry, Pharmaceutical
  • Combinatorial Chemistry Techniques / methods*
  • Cyclohexanecarboxylic Acids / chemistry*
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Cyclohexanecarboxylic Acids