Doxorubicin modulates biological effects of ATP in bone marrow cells in vitro

Yu A Uspenskaya; A B Egorova; V P Nefedov

doi:10.1023/a:1019832914759

Doxorubicin modulates biological effects of ATP in bone marrow cells in vitro

Bull Exp Biol Med. 2002 May;133(5):421-4. doi: 10.1023/a:1019832914759.

Authors

Yu A Uspenskaya¹, A B Egorova, V P Nefedov

Affiliation

¹ Department of Anatomy and Physiology of Agricultural Animals, Krasnoyarsk State Agrarian University.

PMID: 12420049
DOI: 10.1023/a:1019832914759

Abstract

ATP activity in mouse bone marrow cells was studied in in vitro experiments. ATP in physiological and supraphysiological concentrations stimulated blebbing of the plasma membrane. Subacute administration of doxorubicin (inductor of oxidative stress) decreased cell sensitivity to ATP, which corresponded to changes in membrane lipid peroxidation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphate / metabolism*
Animals
Antineoplastic Agents / pharmacology
Bone Marrow Cells / drug effects*
Bone Marrow Cells / metabolism*
Doxorubicin / pharmacology*
Lipid Peroxidation
Male
Mice
Microscopy, Phase-Contrast
Necrosis
Oxidative Stress
Time Factors

Substances

Antineoplastic Agents
Doxorubicin
Adenosine Triphosphate