Electrodiffusion model simulation of rectangular current pulses in a voltage-biased biological channel

J Theor Biol. 2002 Dec 7;219(3):291-9. doi: 10.1006/jtbi.2002.3123.

Abstract

Numerical methods are presented for simulating stochastic-in-time current pulses for an electrodiffusion model of the biological channel, with a fixed applied voltage across the channel. The electrodiffusion model consists of the parabolic advection-diffusion equation coupled either to Gauss' law or Poisson's equation, depending on the choice of boundary conditions. The TRBDF2 method is employed for the advection-diffusion equation. The rectangular wave shape of previously simulated traveling wave current pulses is preserved by the full set of partial differential equations for electrodiffusion.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Diffusion
  • Electrophysiology
  • Ion Channels / physiology*
  • Membrane Potentials
  • Models, Biological*

Substances

  • Ion Channels