Natural PTP1B inhibitors from Broussonetia papyrifera

Rong Min Chen; Li Hong Hu; Tian Ying An; Jia Li; Qiang Shen

doi:10.1016/s0960-894x(02)00757-6

Natural PTP1B inhibitors from Broussonetia papyrifera

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3387-90. doi: 10.1016/s0960-894x(02)00757-6.

Authors

Rong Min Chen¹, Li Hong Hu, Tian Ying An, Jia Li, Qiang Shen

Affiliation

¹ Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.

PMID: 12419367
DOI: 10.1016/s0960-894x(02)00757-6

Abstract

Two new compounds, 8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol (1), 3'-(3-methylbut-2-enyl)-3',4',7-trihydroxyflavane (2) and three known compounds 3,3',4',5,7-pentahydroxyflavone (3), uralenol (4), broussochalcone A (5) were isolated from the roots of Broussonetia papyrifera, and their structures determined by spectroscopic methods. Compounds 1, 3, 4 and 5 significantly show the inhibitory activities against the PTP1B enzyme.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology*
Flavonoids / chemistry*
Flavonoids / isolation & purification
Flavonoids / pharmacology*
Inhibitory Concentration 50
Nuclear Magnetic Resonance, Biomolecular
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases / antagonists & inhibitors*
Rosales / chemistry*

Substances

Enzyme Inhibitors
Flavonoids
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases