Abstract
The structure and absolute configuration of the marine antithrombotic product dysinosin A was confirmed by total synthesis. The strategy involved disconnections to three subunits, of which two were synthesized from the readily available l-glutamic acid, d-leucine, and d-mannitol. The Grubbs olefin metathesis carbocyclization reaction was utilized to prepare two intermediates.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Factor VIIa / antagonists & inhibitors*
-
Indoles / chemistry*
-
Indoles / isolation & purification
-
Indoles / pharmacology
-
Porifera / chemistry*
-
Pyrroles / chemistry*
-
Pyrroles / isolation & purification
-
Pyrroles / pharmacology
-
Serine Proteinase Inhibitors / chemical synthesis*
-
Thrombin / antagonists & inhibitors*
Substances
-
Indoles
-
Pyrroles
-
Serine Proteinase Inhibitors
-
dysinosin A
-
Factor VIIa
-
Thrombin