The mortality associated with undrained intra-abdominal abscesses is high. Computed tomography-guided percutaneous drainage (CT-PD), a minimally invasive technique, allows a drainage catheter to be inserted into fluid collections throughout the body with minimal risk. We described two neutropenic patients with intra-abdominal abscesses treated with CT-PD after they failed to respond to antimicrobial therapy. With this modality, the surgery was successfully avoided or delayed. We are of an opinion that CT-PD is an efficient and simple urgent radiology procedure.