We report on the observation, in a 50-year-old woman undergoing dobutamine stress echocardiography, of the simultaneous onset of complete left bundle branch block and anginal chest pain, unaccompanied by any abnormality of left ventricular segmental contraction or wall thickening. Further etiologic investigations, in particular for coronary artery disease, proved negative. This observation is discussed in the context of a literature review.