Abstract
Twenty-seven oxygenated xanthones have been assessed for their capacity to inhibit in vitro the growth of three human cancer cell lines, MCF-7 (breast cancer), TK-10 (renal cancer) and UACC-62 (melanoma). The effect of these xanthones on the proliferation of human T-lymphocytes was also evaluated. Differences on their potency towards the effect on the growth of the human cancer cell lines as well as on the proliferation of human T-lymphocytes can be ascribed to the nature and positions of the substituents on the xanthonic nucleus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / chemical synthesis
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Adjuvants, Immunologic / pharmacology
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Cell Division / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Lymphocyte Activation / drug effects*
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Phytohemagglutinins / pharmacology
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Structure-Activity Relationship
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T-Lymphocytes / drug effects
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Tumor Cells, Cultured
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Xanthenes / chemical synthesis
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Xanthenes / pharmacology*
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Xanthones*
Substances
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Adjuvants, Immunologic
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Antineoplastic Agents
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Phytohemagglutinins
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Xanthenes
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Xanthones
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xanthone