Synthesis, structural characterization and antimicrobial studies of hydrazone derivatives of 3-hydroxyimino-5-methyl-2-hexanone

Acta Pol Pharm. 2002 Jul-Aug;59(4):291-3.

Abstract

The derivatives of 3-hydroxyimino-5-methyl-2-hexanone oxime have been obtained in good yield by its reactions either with hydrazine hydrate or phenyl hydrazine, respectively. IR and 1H NMR spectral data of these compounds have been discussed. All the newly synthesised compounds have been tested for their biological activity against S. auerus, S. typhi, C. albicans, A. niger, S. cerevisiae and M. tuberculosis H47RV.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Hexanones / chemical synthesis*
  • Hexanones / chemistry
  • Hexanones / pharmacology
  • Hydrazones / chemical synthesis*
  • Hydrazones / chemistry
  • Hydrazones / pharmacology
  • Microbial Sensitivity Tests / methods
  • Microbial Sensitivity Tests / statistics & numerical data
  • Oximes / chemical synthesis*
  • Oximes / chemistry
  • Oximes / pharmacology

Substances

  • Anti-Bacterial Agents
  • Hexanones
  • Hydrazones
  • Oximes