Pachastrissamine, a cytotoxic anhydrophytosphingosine from a marine sponge, Pachastrissa sp

Ikuma Kuroda; Musri Musman; Ikuko I Ohtani; Toshio Ichiba; Junichi Tanaka; Dolores Garcia Gravalos; Tatsuo Higa

doi:10.1021/np010659y

Pachastrissamine, a cytotoxic anhydrophytosphingosine from a marine sponge, Pachastrissa sp

J Nat Prod. 2002 Oct;65(10):1505-6. doi: 10.1021/np010659y.

Authors

Ikuma Kuroda¹, Musri Musman, Ikuko I Ohtani, Toshio Ichiba, Junichi Tanaka, Dolores Garcia Gravalos, Tatsuo Higa

Affiliation

¹ Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.

PMID: 12398554
DOI: 10.1021/np010659y

Abstract

An anhydrophytosphingosine named pachastrissamine (3) has been isolated as a cytotoxic principle of a sponge, Pachastrissa sp., and the structure including the absolute configuration determined by spectroscopic and chemical analysis.

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Porifera / chemistry*
Spectrum Analysis / methods
Sphingosine / analogs & derivatives
Sphingosine / chemistry
Sphingosine / isolation & purification*
Sphingosine / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
pachastrissamine
Sphingosine