New marine diterpenoids from the Okinawan soft coral Clavularia koellikeri

J Nat Prod. 2002 Oct;65(10):1441-6. doi: 10.1021/np0200156.

Abstract

Chemical investigation of the Okinawan soft coral Clavularia koellikeri resulted in the isolation of two new cembrane diterpenoids (1 and 2) and one new dollabelane diterpenoid, 3. Their structures were determined on the basis of the results of spectroscopic analysis. Compounds 1 and 3 were examined for in vitro growth-inhibition effects toward tumor cells.

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Drug Screening Assays, Antitumor
  • Marine Biology
  • Molecular Structure
  • Spectrum Analysis
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Diterpenes