HIV infection is associated with a number of adverse consequences, including metabolic disorders. This article reviews disorders such as wasting, lipid metabolism disorders (including fat redistribution or dyslipidemia), glucose abnormalities, bone disease, and endocrine disorders such as hypogonadism in the presence of HIV infection and/or drug abuse. The issues covered are current estimations of prevalence, risk factors, underlying pathophysiology, diagnosis, and interventions (prevention and treatment) for metabolic complications of HIV and drug abuse.