Specific accumulation and growth inhibitory effects of hybrid liposomes to hepatoma cells in vitro

Koji Nakano; Yasunori Iwamoto; Wataru Takata; Yoko Matsumoto; Ryuichi Ueoka

doi:10.1016/s0960-894x(02)00723-0

Specific accumulation and growth inhibitory effects of hybrid liposomes to hepatoma cells in vitro

Bioorg Med Chem Lett. 2002 Nov 18;12(22):3251-4. doi: 10.1016/s0960-894x(02)00723-0.

Authors

Koji Nakano¹, Yasunori Iwamoto, Wataru Takata, Yoko Matsumoto, Ryuichi Ueoka

Affiliation

¹ Graduate School of Applied Chemistry, Sojo University, Kumamoto, Japan.

PMID: 12392725
DOI: 10.1016/s0960-894x(02)00723-0

Abstract

Specific accumulation and growth inhibitory effects of hybrid liposomes composed of 90 mol% dimyristoylphosphatidylcholine and 10 mol% polyoxyethylene(23)dodecyl ether were obtained in human hepatoma cells without affecting normal liver cells at all.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / metabolism
Antineoplastic Agents / pharmacology
Apoptosis / drug effects
Carcinoma, Hepatocellular / drug therapy
Carcinoma, Hepatocellular / pathology*
Cell Division / drug effects
Dimyristoylphosphatidylcholine
Humans
Kinetics
Liposomes / metabolism
Liposomes / pharmacology*
Polidocanol
Polyethylene Glycols
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Liposomes
Polidocanol
Polyethylene Glycols
Dimyristoylphosphatidylcholine