Abstract
Organic artificial proteases with broad substrate specificity were synthesized by covering the surface of silica gel with aldehyde and the functional groups present in amino acids. The artificial proteases hydrolyzed ovalbumin, albumin, hemoglobin, gamma-globulin with half-lives as short as 50 min at 25 degrees C or 7 min at 50 degrees C.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aldehydes / chemistry*
-
Animals
-
Catalysis
-
Endopeptidases / chemical synthesis*
-
Endopeptidases / chemistry
-
Humans
-
Hydrolysis
-
Kinetics
-
Molecular Mimicry
-
Organic Chemicals / chemistry
-
Proteins / chemistry
-
Proteins / metabolism
-
Silica Gel
-
Silicon Dioxide
-
Substrate Specificity
Substances
-
Aldehydes
-
Organic Chemicals
-
Proteins
-
Silica Gel
-
Silicon Dioxide
-
Endopeptidases