Mutations in ribosomal protein L16 and in 23S rRNA in Enterococcus strains for which evernimicin MICs differ

Antimicrob Agents Chemother. 2002 Nov;46(11):3657-9. doi: 10.1128/AAC.46.11.3657-3659.2002.

Abstract

Mutations in ribosomal protein L16 and in 23S rRNA were investigated in 22 Enterococcus strains of different species and for which the MICs of evernimicin differ (MICs, 0.023 to 16 micro g/ml). Amino acid changes (Arg56His, Ile52Thr, or Arg51His) in protein L16 were found in seven strains, and a nucleotide G2535A mutation in 23S rRNA was found in 1 strain among 13 for which the MICs are > or =1 micro g/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Aminoglycosides*
  • Anti-Bacterial Agents / pharmacology*
  • Enterococcus / drug effects*
  • Enterococcus / genetics*
  • Enterococcus faecalis / drug effects
  • Enterococcus faecalis / genetics
  • Enterococcus faecium / drug effects
  • Enterococcus faecium / genetics
  • Microbial Sensitivity Tests
  • RNA, Ribosomal, 23S / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Ribosomal Proteins / genetics*

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • RNA, Ribosomal, 23S
  • Ribosomal Proteins
  • ribosomal protein L16
  • evernimicin