Aspergillin PZ, a novel isoindole-alkaloid from Aspergillus awamori

J Antibiot (Tokyo). 2002 Aug;55(8):693-5. doi: 10.7164/antibiotics.55.693.

Abstract

Aspergillin PZ was obtained from the fermentation of Aspergillus awamori (Nakazawa) by activity-guided fractionation and purification. Its structure was elucidated on the basis of spectral data, especially by 2D NMR, and finally confirmed by an X-ray analysis. It could induce conidia of P. oryzae to deform moderately.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids* / biosynthesis
  • Alkaloids* / chemistry
  • Alkaloids* / pharmacology
  • Antifungal Agents / pharmacology
  • Ascomycota / drug effects
  • Ascomycota / growth & development
  • Aspergillus / growth & development
  • Aspergillus / metabolism*
  • Gliotoxin* / biosynthesis
  • Gliotoxin* / chemistry
  • Gliotoxin* / pharmacology
  • Indole Alkaloids / chemistry
  • Indole Alkaloids / metabolism
  • Indole Alkaloids / pharmacology
  • Indoles* / chemistry
  • Indoles* / metabolism
  • Indoles* / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Soil Microbiology
  • X-Rays

Substances

  • Alkaloids
  • Antifungal Agents
  • Indole Alkaloids
  • Indoles
  • aspergillin PZ
  • Gliotoxin