Abstract
Atropine is known to be an effective bonrchodilator. We studied the effectiveness of aerosol Sch 1000, a derivative of atropine, in relieving bronchoconstriction in asthma. A single dose of drug was effective within 5 min, and the effect had a duration of 4 hours. No side effects were noted. The major effect of the drug appeared to be in large airways.
MeSH terms
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Adolescent
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Adult
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Aerosols
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Asthma / drug therapy
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Asthma / physiopathology
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Atropine Derivatives*
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Bronchodilator Agents / therapeutic use*
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Clinical Trials as Topic
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Forced Expiratory Volume
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Humans
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Ipratropium / administration & dosage
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Ipratropium / therapeutic use*
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Isoproterenol / administration & dosage
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Isoproterenol / therapeutic use
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Maximal Midexpiratory Flow Rate
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Placebos
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Vital Capacity
Substances
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Aerosols
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Atropine Derivatives
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Bronchodilator Agents
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Placebos
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Ipratropium
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Isoproterenol