Recent advances in topoisomerase I-targeting agents, camptothecin analogues

Mini Rev Med Chem. 2002 Dec;2(6):611-9. doi: 10.2174/1389557023405530.

Abstract

The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Camptothecin / analogs & derivatives*
  • Camptothecin / chemistry
  • Camptothecin / pharmacology
  • Camptothecin / therapeutic use
  • Clinical Trials as Topic
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Enzyme Inhibitors / therapeutic use
  • Humans
  • Molecular Structure
  • Neoplasms / drug therapy
  • Neoplasms / enzymology
  • Structure-Activity Relationship
  • Topoisomerase I Inhibitors*
  • Treatment Outcome

Substances

  • Antineoplastic Agents, Phytogenic
  • Enzyme Inhibitors
  • Topoisomerase I Inhibitors
  • Camptothecin