Abstract
Chemical insights into artemisinin's biological mechanism of action have allowed rational design of some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarizes recent achievements in this area of peroxide drug development for malaria chemotherapy.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Antimanic Agents / chemistry
-
Antimanic Agents / therapeutic use*
-
Humans
-
Malaria / drug therapy*
-
Molecular Structure
-
Peroxides / chemistry
-
Peroxides / therapeutic use*
-
Plasmodium / drug effects*
-
Plasmodium / isolation & purification
-
Structure-Activity Relationship
Substances
-
Antimanic Agents
-
Peroxides