Abstract
A seven-stage synthesis of a pyrrole analogue of chloramphenicol (9) is described. The compound exhibits a significant antibacterial activity, over the 3% to 50% range of the chloramphenicol activity: over the 6% to 100% range of the thiamphenicol activity and florfenicol.
MeSH terms
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Acetamides / chemical synthesis*
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Acetamides / pharmacology*
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects
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Chloramphenicol / analogs & derivatives
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Chloramphenicol / chemical synthesis
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Chloramphenicol / pharmacology
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Microbial Sensitivity Tests / statistics & numerical data
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Pyrroles / chemical synthesis*
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Pyrroles / chemistry
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Pyrroles / pharmacology*
Substances
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1-(1-methylsulfonylpyrrol-3-yl)-2-dichloroacetamidopropane-1,3-diol
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Acetamides
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Anti-Bacterial Agents
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Pyrroles
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Chloramphenicol