Pyrrole analogues of chloramphenicol. III. Synthesis and antibacterial activity of DL-threo-1-(1-methylsulfonylpyrrole-3-yl)-2-dichloroacetamidopropane-1,3-diol

Acta Pol Pharm. 2002 Mar-Apr;59(2):127-32.

Abstract

A seven-stage synthesis of a pyrrole analogue of chloramphenicol (9) is described. The compound exhibits a significant antibacterial activity, over the 3% to 50% range of the chloramphenicol activity: over the 6% to 100% range of the thiamphenicol activity and florfenicol.

MeSH terms

  • Acetamides / chemical synthesis*
  • Acetamides / pharmacology*
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects
  • Chloramphenicol / analogs & derivatives
  • Chloramphenicol / chemical synthesis
  • Chloramphenicol / pharmacology
  • Microbial Sensitivity Tests / statistics & numerical data
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry
  • Pyrroles / pharmacology*

Substances

  • 1-(1-methylsulfonylpyrrol-3-yl)-2-dichloroacetamidopropane-1,3-diol
  • Acetamides
  • Anti-Bacterial Agents
  • Pyrroles
  • Chloramphenicol