Effect of microcrystalline chitosan on the solubility of ibuprofen

Acta Pol Pharm. 2002 Mar-Apr;59(2):105-8.

Abstract

It was found that MCCh may be used for the enhancement of the solubility and dissolution rates of drugs. The solubility of IBA in water increased significantly (about 10-fold) when MCCh was added. Differential scanning calorimetry (DSC), powder X-ray diffractometry, and IR spectroscopy were used to confirm that salt links between the drug and MCCh occurred.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chitin / analogs & derivatives*
  • Chitin / chemistry*
  • Chitosan
  • Crystallization
  • Drug Carriers / chemistry
  • Ibuprofen / chemistry*
  • Solubility / drug effects

Substances

  • Drug Carriers
  • Chitin
  • Chitosan
  • Ibuprofen