Hormesis is the stimulation of a biological response at low concentrations of an inhibitor. Ethanolic extracts were made using Osmundaria serrata (Suhr) R. E. Norris and Stypopodium zonale (Lamouroux) Papenfuss from the East coast of South Africa. Two plant pathogens (Colletotrichum gloeosporioides (Penz.) Penz. and Sacc. and Rhizoctonia solani Kühn) were used as test organisms in bioassays. Serial dilutions of macroalgal extracts were tested by the pour plate technique. Both growth inhibitory and promotory responses were observed. The hormetic response was observed in both the fungi when grown on low dilutions of ethanol and the O. serrata extract, and when R. solani was grown on the S. zonale extract. This study provides more evidence of hormesis in macroalgal products and the phenomenon is discussed in relation to its possible cause and significance in the application of seaweed extracts.