The use of antiseptics for wound care has long been controversial. Antiseptics have a broad spectrum of activity that, in addition to making them effective against a broad range of microorganisms, makes them toxic to living human tissue. Consequently antiseptics gradually fell out of favour following the introduction of systemic antibiotics. In recent years, however, there has been renewed interest in antiseptics as a result of the evolution of antibiotic-resistant bacteria, and considerable funds are being invested in the development of modern antiseptic dressings. This article aims to discuss some of these issues and set them in a practical context so that readers recognize the complexities of decision-making where antiseptics are concerned. This in turn should enable them to make a better-informed choice for their patients or, where appropriate, seek expert advice.