Abstract
The stem bark of Cedrelopsis microfoliata has yielded the new compounds microfolian (1), microfolione (2), and microfolicoumarin (6) along with the known compounds agrandol (3), cedrecoumarin A (4), obliquin (5), and sesquichamaenol (7). Compounds 2-4 were found to show agonistic activity on both alpha- and beta-estrogenic receptors, and compounds 1, 3, and 4 were shown to inhibit the chemiluminescence of reactive oxygen metabolites and showed superoxide scavenging activity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Benzene Derivatives / chemistry
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Benzene Derivatives / isolation & purification*
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Benzene Derivatives / pharmacology
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Cells, Cultured / drug effects
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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Humans
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Kidney
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Luciferases / metabolism
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Luminescent Measurements
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Madagascar
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Receptors, Estrogen / metabolism
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Sapindaceae / chemistry*
Substances
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Benzene Derivatives
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Free Radical Scavengers
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Receptors, Estrogen
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Luciferases