Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852)

Sei-Joon Jeong; Ryuichi Higuchi; Tomofumi Miyamoto; Mayumi Ono; Michihiko Kuwano; Shunsuke F Mawatari

doi:10.1021/np010577+

Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852)

J Nat Prod. 2002 Sep;65(9):1344-5. doi: 10.1021/np010577+.

Authors

Sei-Joon Jeong¹, Ryuichi Higuchi, Tomofumi Miyamoto, Mayumi Ono, Michihiko Kuwano, Shunsuke F Mawatari

Affiliation

¹ Graduate School of Pharmaceutical Sciences and Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

PMID: 12350162
DOI: 10.1021/np010577+

Abstract

A new antiangiogenic compound, bryoanthrathiophene (1), together with two known compounds, 5,7-dihydroxy-1-methoxycarbonyl-6-oxo-6H-anthra[1,9-bc]thiophene (2) and 1,8-dihydroxyanthraquinone (3), was isolated from the bryozoan Watersipora subtorquata (d'Orbigny, 1852) using bioassay-guided fractionation methods. Among them, bryoanthrathiophene (1) exhibited the most potent antiangiogenic activity on BAEC (bovine aorta endothelial cell) proliferation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiogenesis Inhibitors / chemistry
Angiogenesis Inhibitors / isolation & purification*
Angiogenesis Inhibitors / pharmacology
Animals
Anthraquinones / chemistry
Anthraquinones / isolation & purification*
Anthraquinones / pharmacology
Aorta / cytology*
Aorta / drug effects*
Bryozoa / chemistry*
Cattle
Cells, Cultured / drug effects
Endothelium, Vascular / drug effects*
Japan
Lymphokines
Thiophenes / chemistry
Thiophenes / isolation & purification*
Thiophenes / pharmacology

Substances

5,7-dihydroxy-1-methoxycarbonyl-6-oxo-6H-anthra(1,9-bc)thiophene
Angiogenesis Inhibitors
Anthraquinones
Lymphokines
Thiophenes
bryoanthrathiophene
danthron