Abstract
Four beta-carbolines, plakortamines A-D, two cyclic peroxides, epiplakinic acids G and H, and two related gamma-lactones, (2S,4R)- and (2R,4R)-2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactones, were isolated from the deep-water sponge Plakortis nigra from Palau. The structures of the eight new metabolites were elucidated by interpretation of spectroscopic data. Most of the metabolites inhibited the HCT-116 human colon tumor cell line.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Carbolines / chemistry
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Carbolines / isolation & purification*
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Carbolines / pharmacology
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Colonic Neoplasms
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Palau
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Peroxides / chemistry
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Peroxides / isolation & purification*
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Peroxides / pharmacology
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Porifera / chemistry*
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Spectroscopy, Fourier Transform Infrared
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Stereoisomerism
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents
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Carbolines
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Peroxides