[Methods of determination of fluoxetine nad fluvoxamine]

Abstract

Two selective serotonin reuptake inhibitors (SSRIs) have been introduced: fluoxetine and fluvoxamine. The literature review shows most methods allow quantitative determination of SSRIs pharmaceutical preparations and plasma, in the lower ng/ml range and that they are, therefore, suitable for therapeutic drug monitoring purposes of this category of drugs. Most procedures are based on investigation of this drugs by spectrophotometric, electrochemical and chromatographic procedures with detection by various detectors.