Novel spermine-based cationic gemini surfactants for gene delivery

G Ronsin; C Perrin; P Guédat; A Kremer; P Camilleri; A J Kirby

doi:10.1039/b105936j

Novel spermine-based cationic gemini surfactants for gene delivery

Chem Commun (Camb). 2001 Nov 7:(21):2234-5. doi: 10.1039/b105936j.

Authors

G Ronsin¹, C Perrin, P Guédat, A Kremer, P Camilleri, A J Kirby

Affiliation

¹ University Chemical Laboratory, Lensfield Road, Cambridge, UK CB1 1EW.

PMID: 12240127
DOI: 10.1039/b105936j

Abstract

Two types of spermine-based gemini surfactants have been synthesised; structure-activity studies have shown one type to be far superior in gene transection than the other.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line
DNA / genetics
Gene Transfer Techniques*
Spermine / analogs & derivatives*
Spermine / chemistry*
Structure-Activity Relationship
Surface-Active Agents / chemistry*
Transfection

Substances

Surface-Active Agents
Spermine
DNA