New biologically active marine sesquiterpenoid and steroid from the okinawan sponge of the genus Axinyssa

Chem Pharm Bull (Tokyo). 2002 Sep;50(9):1286-9. doi: 10.1248/cpb.50.1286.

Abstract

A new bisabolane-type sesquiterpenoid, (E)-3-isocyanobisabolane-7,10-diene (1), and a new epidioxyergostane-type steroid, 9(11)-dehydroaxinysterol (2), were isolated from the Okinawan sponge of the genus Axinyssa. Their structures were elucidated based on the results of spectroscopic analysis and chemical conversion. Epidioxysterol 2 was found to show significant growth inhibitory effects against human cancer cell lines.

MeSH terms

  • Alkenes / chemistry
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology*
  • Artemia
  • Catalysis
  • Drug Screening Assays, Antitumor
  • Ergosterol / chemistry
  • Ergosterol / isolation & purification
  • Humans
  • Hydrogenation
  • Japan
  • Lethal Dose 50
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Models, Molecular
  • Oxidation-Reduction
  • Porifera / chemistry*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology*
  • Steroids / chemistry
  • Steroids / isolation & purification*
  • Steroids / pharmacology*

Substances

  • Alkenes
  • Antineoplastic Agents
  • Sesquiterpenes
  • Steroids
  • Ergosterol