Abstract
A new bisabolane-type sesquiterpenoid, (E)-3-isocyanobisabolane-7,10-diene (1), and a new epidioxyergostane-type steroid, 9(11)-dehydroaxinysterol (2), were isolated from the Okinawan sponge of the genus Axinyssa. Their structures were elucidated based on the results of spectroscopic analysis and chemical conversion. Epidioxysterol 2 was found to show significant growth inhibitory effects against human cancer cell lines.
MeSH terms
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Alkenes / chemistry
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Artemia
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Catalysis
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Drug Screening Assays, Antitumor
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Ergosterol / chemistry
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Ergosterol / isolation & purification
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Humans
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Hydrogenation
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Japan
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Lethal Dose 50
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Models, Molecular
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Oxidation-Reduction
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Porifera / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology*
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Steroids / chemistry
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Steroids / isolation & purification*
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Steroids / pharmacology*
Substances
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Alkenes
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Antineoplastic Agents
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Sesquiterpenes
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Steroids
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Ergosterol