Abstract
Seven morpholin derivatives were synthesized (compounds 1-7) and their behavioural effects were evaluated; the elements considered were locomotor activity, motor coordination, catalepsy, stereotyped behaviour and antinociception. All the compounds, at doses of 10-20-40 mg/kg/i.p., induced a reduction of all behavioural elements without a significant antinociceptive effect. These results indicate that these morpholin derivatives affect the central nervous system.
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Central Nervous System Agents / chemical synthesis*
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Central Nervous System Agents / chemistry
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Central Nervous System Agents / pharmacology
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, Thin Layer
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Computer Simulation
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Dose-Response Relationship, Drug
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Grooming / drug effects
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Models, Molecular
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Molecular Conformation
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Morpholines / chemical synthesis*
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Morpholines / pharmacology
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Motor Activity / drug effects
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Postural Balance / drug effects
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Spectrophotometry, Infrared
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Structure-Activity Relationship
Substances
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Central Nervous System Agents
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Indicators and Reagents
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Morpholines