In vitro activities of investigational triazoles against Fusarium species: effects of inoculum size and incubation time on broth microdilution susceptibility test results

Niki I Paphitou; Luis Ostrosky-Zeichner; Victor L Paetznick; Jose R Rodriguez; Enuo Chen; John H Rex

doi:10.1128/AAC.46.10.3298-3300.2002

In vitro activities of investigational triazoles against Fusarium species: effects of inoculum size and incubation time on broth microdilution susceptibility test results

Antimicrob Agents Chemother. 2002 Oct;46(10):3298-300. doi: 10.1128/AAC.46.10.3298-3300.2002.

Authors

Niki I Paphitou¹, Luis Ostrosky-Zeichner, Victor L Paetznick, Jose R Rodriguez, Enuo Chen, John H Rex

Affiliation

¹ Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas-Houston Medical School, 77030, USA. GMIX@msn.com

Abstract

We studied the effects of inoculum size and incubation time on the susceptibility testing results for various antifungal agents against 22 Fusarium isolates by the NCCLS microdilution method. Increased inoculum size and extended incubation time resulted in elevated MICs. Posaconazole and voriconazole exhibited promising antifungal activities.

Publication types

Evaluation Study

MeSH terms

Antifungal Agents / pharmacology*
Colony Count, Microbial
Culture Media
Fusarium / drug effects*
Fusarium / growth & development
Humans
Microbial Sensitivity Tests / methods
Microbial Sensitivity Tests / standards
Pyrimidines / pharmacology
Triazoles / pharmacology*
Voriconazole

Substances

Antifungal Agents
Culture Media
Pyrimidines
Triazoles
posaconazole
Voriconazole