Abstract
Six new macrolides, amphidinolides H2 (5), H3 (6), H4 (7), H5 (8), G2 (9), and G3 (10), have been isolated from a marine dinoflagellate Amphidinium sp. (strain Y-42). Cytotoxicity of five derivatives (11-15) of amphidinolide H (1) in addition to 10 amphidinolides (1-10) containing amphidinolides H (1), G (2), B (3), and D (4) was examined, and it was found that the presence of an allyl epoxide, an S-cis-diene moiety, and the ketone at C-20 was important for the cytotoxicity of amphidinolide H (1)-type macrolides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Survival / drug effects
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Dinoflagellida / chemistry*
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Drug Screening Assays, Antitumor
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Humans
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Japan
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KB Cells / drug effects
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Leukemia
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Marine Toxins / chemistry
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Marine Toxins / isolation & purification*
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Marine Toxins / pharmacology
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Mice
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Stereoisomerism
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Structure-Activity Relationship
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Tumor Cells, Cultured / drug effects
Substances
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Macrolides
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Marine Toxins
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amphidinolide H