Abstract
[reaction: see text] The asymmetric synthesis of the natural product (+)-epoxyquinol A (1) and related epoxyquinoid dimers, employing a cascade oxidation/electrocyclization/Diels-Alder dimerization sequence, is reported. In addition, we show that 1 and related molecules inhibit activation of the transcription factor NF-kappaB.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / chemical synthesis*
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Angiogenesis Inhibitors / chemistry
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Crystallography, X-Ray
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Epoxy Compounds / chemical synthesis*
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Epoxy Compounds / chemistry
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Hydroquinones / chemical synthesis*
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Hydroquinones / chemistry
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Molecular Conformation
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Molecular Structure
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NF-kappa B / antagonists & inhibitors*
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NF-kappa B / metabolism
Substances
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Angiogenesis Inhibitors
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Epoxy Compounds
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Hydroquinones
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NF-kappa B
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epoxyquinol A