Effects of the N-salicylaladehyde Aminoglucose Schiff Base Complexes no O(2)(-). and DNA

Xiao-Qin Liu; Jian-Lin Wang; Zhi-Feng Le; Chang-Jian Feng; Hao-Yu Shen; Xiang-Cai Zhang

Effects of the N-salicylaladehyde Aminoglucose Schiff Base Complexes no O(2)(-). and DNA

Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1997;29(1):76-81.

Authors

Xiao-Qin Liu¹, Jian-Lin Wang, Zhi-Feng Le, Chang-Jian Feng, Hao-Yu Shen, Xiang-Cai Zhang

Affiliation

¹ Hubei Sanxia College Medical College, Yichang 443003, China.

PMID: 12219240

Abstract

The effects of SG schiff base complexes with Cu(II), Zn(II), Co(III) on O(2)(-). and DNA were studied. The results showed that both CuSG and ZnSG could an inhibit the synthesis of O(2)(-). markedly. The inhibiting effect of CuSG was larger than that of ZnSG. Complexes CuSG and CoSG could also combine with the salmon sperm DNA. The intrinsic association constant (K(0)) for CuSG and CoSG were estimated to be 2.86x10(4) M(-1 and 1.29x105) M-1 respectively. The numbers of binding sites per 100 nucleotide (n) were 2.5 and 7.5 respectively.