Synthesis and anticancer evaluation of vitamin K(3) analogues

Bioorg Med Chem Lett. 2002 Oct 7;12(19):2729-32. doi: 10.1016/s0960-894x(02)00532-2.

Abstract

Novel vitamin K(3) analogues were synthesized and evaluated for their anticancer activity. Compound 6, 9, 10, 11, 14, and (+/-)15 demonstrated a strong inhibitory activity against the tumor cells of A-549, Hep G2, MCF7, MES-SA, MES-SA/Dx5, MKN45, SW-480, and TW-039. Compound (+/-)15 displayed potent tumor cell cytotoxicity, and compound 14 selectively affected MCF7, even though it did not influence normal cells Detroit551 and WI-38. Compound (+/-)15 inhibited MES-SA and MES-SA/Dx5, and this specific result shows that compound (+/-)15 may become a good anticancer drug candidate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology*
  • Genes, MDR
  • Humans
  • Indicators and Reagents
  • Tumor Cells, Cultured
  • Vitamin K 3 / analogs & derivatives*
  • Vitamin K 3 / chemical synthesis
  • Vitamin K 3 / pharmacology*

Substances

  • Antineoplastic Agents
  • Indicators and Reagents
  • Vitamin K 3