Analogues of aspartic proteases synthesized by densely covering silica gel with carboxyl groups

Bioorg Med Chem Lett. 2002 Oct 7;12(19):2663-6. doi: 10.1016/s0960-894x(02)00567-x.

Abstract

Aspartic protease analogues synthesized by covering the surface of silica gel with carboxyl groups effectively hydrolyzed hemoglobin and gamma-globulin. It is proposed that the carboxyl group is involved in both complexation of the protein substrate and the catalytic cleavage of the peptide bonds of the complexed proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Albumins / chemistry
  • Aspartic Acid Endopeptidases / chemical synthesis*
  • Aspartic Acid Endopeptidases / chemistry
  • Catalysis
  • Hemoglobins / chemistry
  • Hydrolysis
  • Kinetics
  • Ovalbumin / chemistry
  • Peptides / chemistry
  • Silica Gel
  • Silicon Dioxide / chemistry*
  • gamma-Globulins / chemistry

Substances

  • Albumins
  • Hemoglobins
  • Peptides
  • gamma-Globulins
  • Silica Gel
  • Silicon Dioxide
  • Ovalbumin
  • Aspartic Acid Endopeptidases