Abstract
Aspartic protease analogues synthesized by covering the surface of silica gel with carboxyl groups effectively hydrolyzed hemoglobin and gamma-globulin. It is proposed that the carboxyl group is involved in both complexation of the protein substrate and the catalytic cleavage of the peptide bonds of the complexed proteins.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adsorption
-
Albumins / chemistry
-
Aspartic Acid Endopeptidases / chemical synthesis*
-
Aspartic Acid Endopeptidases / chemistry
-
Catalysis
-
Hemoglobins / chemistry
-
Hydrolysis
-
Kinetics
-
Ovalbumin / chemistry
-
Peptides / chemistry
-
Silica Gel
-
Silicon Dioxide / chemistry*
-
gamma-Globulins / chemistry
Substances
-
Albumins
-
Hemoglobins
-
Peptides
-
gamma-Globulins
-
Silica Gel
-
Silicon Dioxide
-
Ovalbumin
-
Aspartic Acid Endopeptidases