Molecular prognostic indicators in breast cancer

C E Rogers; R L Loveday; P J Drew; J Greenman

doi:10.1053/ejso.2002.1258

Molecular prognostic indicators in breast cancer

Eur J Surg Oncol. 2002 Aug;28(5):467-78. doi: 10.1053/ejso.2002.1258.

Authors

C E Rogers¹, R L Loveday, P J Drew, J Greenman

Affiliation

¹ University of Hull Academic Surgical Unit, Castle Hill Hospital, Castle Road, Cottingham, Hull HU16 5JQ, UK.

PMID: 12217298
DOI: 10.1053/ejso.2002.1258

Abstract

Here we review a panel of oncogene products, proteases and markers of proliferation that have shown potential as prognostic indicators in primary breast cancer. The relative merits of specific genetic mutations as well as alterations at the protein level are discussed. Finally an assessment is made of the transfer of knowledge from the laboratory to the bed-side.

Publication types

Review

MeSH terms

Biomarkers, Tumor* / genetics
Breast Neoplasms / diagnosis*
Breast Neoplasms / genetics
Female
Gene Expression Regulation, Neoplastic / genetics
Genetic Predisposition to Disease
Humans
Indicators and Reagents
Mutation / genetics
Neoplasm Proteins / genetics
Prognosis
Women's Health

Substances

Biomarkers, Tumor
Indicators and Reagents
Neoplasm Proteins