Using immunohistochemistry staining and Western-blot techniques, we detected the distribution and content of vitronectin antigen in placenta tissue of one case of hypertensive pregnancy in order to explore pathogenesis of the development of hypertensive pregnancy. The results were that vitronectin expressions on hypertensive pregnant placenta were obviously higher than those on normal placenta, which suggests that fibrin deposition on placenta tissue was associated with suppression of fibrinolysis.