Long-term follow-up of globus pallidus chronic stimulation in advanced Parkinson's disease

Mov Disord. 2002 Jul;17(4):803-7. doi: 10.1002/mds.10128.

Abstract

To assess the long-term follow-up of the globus pallidus internus (GPi) stimulation, six patients were evaluated every year by using the Unified Parkinson's Disease Rating Scale (UPDRS). Three years postoperatively, GPi stimulation led to a significant improvement of dyskinesia severity (50%, P = 0.05) and activities of daily living (subscore of quality of life scale, 9%, P = 0.05). However, the improvement induced by chronic pallidal stimulation on the mean daily duration in the off state was lost at the last assessment.

MeSH terms

  • Activities of Daily Living / classification
  • Aged
  • Antiparkinson Agents / administration & dosage
  • Combined Modality Therapy
  • Dominance, Cerebral / physiology
  • Electric Stimulation Therapy*
  • Electrodes, Implanted
  • Female
  • Follow-Up Studies
  • Globus Pallidus / physiopathology*
  • Humans
  • Levodopa / administration & dosage
  • Male
  • Middle Aged
  • Motor Skills / physiology
  • Parkinson Disease / diagnosis
  • Parkinson Disease / physiopathology
  • Parkinson Disease / therapy*
  • Quality of Life

Substances

  • Antiparkinson Agents
  • Levodopa