Objective: To investigate the effect of TMCZCJ on the blood rheology in hypostasis rats due to stagnation of the liver-qi and on the learning-memory disorder in cerebral ischemia-reperfusion mice.
Method: The models of hypostasis due to stagnation of the liver-qi were made by combining irritation with hypodemic injected adrenalin and ice-bath in rats, and the models of learning-memory disorder were made by repeatedly ligating-reperfusing the bilateral carotid in mice. The hypostasis rats and learning-memory disorder mice were perorally administrated TMCZCJ(7.7, 15.4 g.kg-1) once a day, for fourteen consecutive days.
Result: TMCZCJ can significantly reduce plasma viscosity, blood viscosity and reduced viscosity in hypostasis rats. It can also improve the latent learning-memory capability and memory gain-repetition ability in water-maze for cerebral ischemia-reperfusion mice.
Conclusion: TMCZCJ can improve remarkably blood rheology in hypostasis rats and learning-memory disorder in cerebral ischemia-reperfusion mice.