Reflections on a novel therapeutic candidate

Letha J Sooter; Andrew D Ellington

doi:10.1016/s1074-5521(02)00190-4

Reflections on a novel therapeutic candidate

Chem Biol. 2002 Aug;9(8):857-8. doi: 10.1016/s1074-5521(02)00190-4.

Authors

Letha J Sooter¹, Andrew D Ellington

Affiliation

¹ Department of Chemistry and Biochemistry, Institute for Cell and Molecular Biology, University of Texas at Austin, 78712, USA.

PMID: 12204684
DOI: 10.1016/s1074-5521(02)00190-4

Abstract

Aptamers composed of L-nucleic acids, Spiegelmers, were selected to specifically bind GnRH. Spiegelmer inhibition of GnRH activity was demonstrated in both cellular and animal models. Rabbit studies showed minimal immunogenic response to the agents.

Publication types

Review

MeSH terms

Animals
Drug Design
Drug Evaluation, Preclinical
Gene Library
Gonadotropin-Releasing Hormone / antagonists & inhibitors*
Humans
Nucleic Acids / chemistry
Nucleic Acids / pharmacology*
Nucleic Acids / therapeutic use

Substances

Nucleic Acids
Gonadotropin-Releasing Hormone