Abstract
[structure: see text] Two novel antiinsectan indole diterpenoids, thiersinines A (1) and B (2), along with seven known paxilline-type compounds, were isolated from organic extracts of a new Penicillium species (P. thiersii NRRL 28147). The structures of 1 and 2 were determined by analysis of 2D NMR data. Thiersinines A and B possess a unique spirocyclic subunit that is unprecedented in previously known compounds of this class. Both compounds exhibit potent activity against the fall armyworm (Spodoptera frugiperda).
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Indoles / chemistry
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Indoles / isolation & purification*
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Insecticides / chemistry
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Insecticides / isolation & purification*
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Insecticides / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Penicillium / chemistry*
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Spiro Compounds
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Spodoptera / drug effects
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Spodoptera / growth & development
Substances
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Diterpenes
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Indoles
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Insecticides
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Spiro Compounds
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thiersinine A
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thiersinine B
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paxilline