BNAs: novel nucleic acid analogs with a bridged sugar moiety

Chem Commun (Camb). 2002 Aug 21:(16):1653-9. doi: 10.1039/b201557a.

Abstract

This article deals with our recent studies on the synthesis of BNAs (Bridged Nucleic Acids), novel nucleic acid analogs bearing a preorganized sugar conformation by a bridged structure. Duplex- and triplex-forming abilities of the BNA modified oligonucleotides are also described.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Base Pairing
  • Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry
  • Molecular Structure
  • Nucleic Acid Conformation
  • Nucleic Acids / chemical synthesis*
  • Nucleic Acids / chemistry
  • Oligodeoxyribonucleotides, Antisense / chemistry
  • Pentoses / chemical synthesis*
  • Pentoses / chemistry

Substances

  • Bridged Bicyclo Compounds, Heterocyclic
  • Nucleic Acids
  • Oligodeoxyribonucleotides, Antisense
  • Pentoses