Molecular imprinted polymer coated QCM for the detection of nandrolone

Analyst. 2002 Aug;127(8):1024-6. doi: 10.1039/b204949j.

Abstract

An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively screen for nandrolone in the liquid phase. A highly specific covalently imprinted polymer (MIP) was spin coated onto one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the nandrolone was observed as a frequency shift in the QCM for concentrations up to 0.2 ppm with the sensor binding shown to favour nandrolone over analogous compounds.

MeSH terms

  • Anabolic Agents / urine*
  • Electrochemistry
  • Electrophoresis / instrumentation
  • Epitestosterone / urine
  • Flow Injection Analysis
  • Humans
  • Nandrolone / urine*
  • Polymers
  • Sensitivity and Specificity
  • Substance Abuse Detection / methods*
  • Testosterone / urine

Substances

  • Anabolic Agents
  • Polymers
  • Testosterone
  • Epitestosterone
  • Nandrolone