Abstract
B lymphocyte stimulator (BLyS) protein is among the novel tumor necrosis factor (TNF) ligands and receptor superfamily members recently described. BLyS protein can promote B cell survival, expansion, and differentiation both and. Constitutive overexpression of BLyS protein can result in systemic lupus erythematosus (SLE)-like disease in mice, and circulating levels of BLyS protein are elevated in a subset of human SLE patients. Treatment of SLE mice with a BLyS protein antagonist ameliorates disease progression and enhances survival. By inference, BLyS protein may also play an important contributory role in pathogenesis and/or propagation of human SLE and becomes a legitimate candidate target for antagonist biologic agents.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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B-Cell Activation Factor Receptor
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B-Lymphocytes / metabolism
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Disease Models, Animal
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Humans
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Lupus Erythematosus, Systemic / immunology
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Lupus Erythematosus, Systemic / metabolism*
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Membrane Proteins*
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Mice
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Mice, Transgenic
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Neuropeptides / metabolism
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Nuclear Proteins / metabolism
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Receptors, Tumor Necrosis Factor / antagonists & inhibitors
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Receptors, Tumor Necrosis Factor / biosynthesis*
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Receptors, Tumor Necrosis Factor / immunology
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Receptors, Tumor Necrosis Factor / metabolism
Substances
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ANP32B protein, human
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B-Cell Activation Factor Receptor
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BLyS receptor
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Membrane Proteins
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Neuropeptides
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Nuclear Proteins
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Receptors, Tumor Necrosis Factor
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TNFRSF13C protein, human
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Tnfrsf13c protein, mouse