Voltammetric determination of fenbendazole in veterinarian formulations

J Pharm Biomed Anal. 2002 Sep 5;30(2):279-84. doi: 10.1016/s0731-7085(02)00339-4.

Abstract

A versatile voltammetric method for quantitative determination of fenbendazole (FBZ) in commercial tablets has been proposed, where direct dissolution of tablets is carried out in 0.1 mol l(-1) tetrabutylamoniun tetrafluorborate containing dimethylformamide solutions. Linear sweep (LSV), square wave (SWV) and differential pulse (DPV) voltammetry techniques were applied to study FBZ at a glassy carbon electrode, exhibiting a well defined irreversible oxidation peak at 1.15 V vs. SCE. This methodology allows a precise quantitative determination of FBZ presenting detection limits of 5.2 x 10(-5) (LSV), 5.0 x 10(-6) (DPV) and 5.0 x 10(-5) mol l(-1) (SWV).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Electrochemistry
  • Fenbendazole / analysis*
  • Fenbendazole / chemistry
  • Veterinary Drugs / analysis
  • Veterinary Drugs / chemistry

Substances

  • Veterinary Drugs
  • Fenbendazole