Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides

Bioorg Med Chem Lett. 2002 Sep 16;12(18):2635-7. doi: 10.1016/s0960-894x(02)00511-5.

Abstract

Synthesis of novel polycationic lipophilic peptide core(s) was accomplished and these agents successfully transfected human retinal pigment epithelium cells with ODN1 upon complexation with the oligonucleotide. The level of transfection was indirectly measured by the decreased production of the protein hVEGF (human vascular endothelial growth factor) in comparison to the transfection agent cytofectin GSV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Endothelial Growth Factors / genetics
  • Humans
  • Intercellular Signaling Peptides and Proteins / genetics
  • Lymphokines / genetics
  • Oligonucleotides / chemistry*
  • Oligonucleotides / genetics
  • Peptides / chemistry*
  • Polyamines / chemical synthesis*
  • Polyamines / chemistry
  • Polyelectrolytes
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Endothelial Growth Factors
  • Intercellular Signaling Peptides and Proteins
  • Lymphokines
  • Oligonucleotides
  • Peptides
  • Polyamines
  • Polyelectrolytes
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • polycations