4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

Bioorg Med Chem Lett. 2002 Sep 16;12(18):2615-9. doi: 10.1016/s0960-894x(02)00470-5.

Abstract

Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers.

MeSH terms

  • Aminoquinolines / chemistry
  • Aminoquinolines / pharmacology*
  • Excitatory Amino Acid Antagonists / chemistry
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
  • Structure-Activity Relationship

Substances

  • Aminoquinolines
  • Excitatory Amino Acid Antagonists
  • Receptors, N-Methyl-D-Aspartate