Abstract
Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers.
MeSH terms
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Aminoquinolines / chemistry
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Aminoquinolines / pharmacology*
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Excitatory Amino Acid Antagonists / chemistry
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Excitatory Amino Acid Antagonists / pharmacology*
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Aminoquinolines
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Excitatory Amino Acid Antagonists
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Receptors, N-Methyl-D-Aspartate