Invasive airway aspergillosis with new airflow obstruction mimicking post-BMT bronchiolitis obliterans

Bone Marrow Transplant. 2002 Apr;29(8):711-3. doi: 10.1038/sj.bmt.1703553.

Abstract

A 52-year-old male with severe gastrointestinal graft-versus-host disease (GVHD), developed dyspnea and irreversible airflow obstruction, 11 weeks post-allogeneic bone marrow stem cell transplantation. Based on the clinical picture and presence of 'mosaic attenuation' pattern on chest high-resolution computerized tomography (HRCT), he was presumed to have bone marrow transplantation-related bronchiolitis obliterans. Post-mortem examination revealed invasive airway aspergillosis with no evidence of bronchiolitis obliterans.

Publication types

  • Case Reports

MeSH terms

  • Airway Obstruction / etiology*
  • Aspergillosis / diagnosis
  • Aspergillosis / etiology*
  • Bronchiolitis Obliterans / diagnosis
  • Diagnosis, Differential
  • Fatal Outcome
  • Graft vs Host Disease / etiology
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Leukemia, Myeloid, Chronic-Phase / therapy
  • Lung Diseases, Fungal / diagnosis
  • Lung Diseases, Fungal / etiology*
  • Male
  • Middle Aged
  • Transplantation, Homologous